I only send out about 35 cards and I use the same design for all the cards. I'll change something about the card, i.e., color of ribbon, if I run out of the ribbon I started off with but I won't change the design. I don't particularly enjoy mass producing cards but I don't want to spend the time coming up with a bunch of different Xmas card designs either. In general, I keep the design for Xmas cards clean and simple cause I know they're only going to get trashed anyway.
I don't know how it is for anyone else but my family and friends keep the cards I make and send to them for everything else that goes on throughout the year but none of them keep the Xmas cards they receive from anyone. And I have to admit I don't keep any Xmas cards that are sent to me/family, either.