Well... McCain picked Palin, who was ultra-conservative also... and he lost, so maybe Romney will lose because Ryan is also ultra-conservative? Don't most Republicans believe in Fetal Personhood?? Isn't that why most Republicans want to do away with abortion?? Because they want less government in all things except for the uterus.
Edited to add: I think that if most people knew that Ryan believes in Fetal Personhood, the Republican half would still vote for them, and the Democrat half still wouldn't.